Final exam لمادة صيدلة سريرية ٢ ( الامتحان مشترك)

Q1 Score: 0.35

A- the most biologic DMARDs

B- they block TNF, which is a cytokine involved in the infkammato process

C- all TNF alpha inhibitors they are different Indication

D- Adalimumab is treat of Anti- TNF drug

Q2 Score: 0.35

A- NSAID+ PPI

B- NSAID+ prostaglandin analog

C- NSAID+ ASPIRIN

D- NSAID+ full dose histamine H2 blockers daily

Q3 Score: 0.35

A- methotrexate is a JAK inhibitors for use in patients with moderate to severe RA

B- adverse effects of JAK inhibitors they are similar to other biologic agents

C- is the targeted synthetic DMARDs

D- results in modulation and suppression of the immune system through cytokines signal reduction

Q4 Score: 0.35

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Q5 Score: 0.35

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Q6 Score: 0.35

A- meditation

B- psychotherapy

C- short term counseling

D- exercise

E- psycho- education

Q7 Score: 0.35

A- Bupropion

B- Venlafaxine

C- Aspirin

D- flecainide

Q8 Score: 0.35

A- uses age of onset : 35- 50 years

B- joint pattern is symmetric

C- ESR is normal

D- speed of onset is rapid

Q9 Score: 0.35

A- dosing of Infliximab is given by IV infusions

B- Etanercept is should be laboratory monitoring is required

C- MOA of Adlimumab is a chimeric antibody combining portions of mouse

D- certolizumab is FDA approved for use in JIA

Q10 Score: 0.35

A- the life time prevalence of anxiety disorder among American adult is 50%

B- SAD is the most common anxiety disorder

C- the female - to male ratio for any life time anxiety disorder is 1:2

D- all the above

Q11 Score: 0.35

A- EST

B- myths

C- light therapy

D- exercise

Q12 Score: 0.35

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Q13 Score: 0.35

A- because adverse effect includes gastropathy

B- low therapeutic index

C- mucous membranes of the respitory trat

D- non the above

Q14 Score: 0.35

A- dry mouth is symptoms of PD

B- PET scan are used to visualize dopamine uptake in the substantia nigra and basal ganglia

C- the goal in the management of IPD is to improve motor and non motor symptoms

D- lifestyle modification is treatment of non pharmacologic therapy by PD

Q15 Score: 0.35

A- is symptomatic therapy of motor symptoms in early PD

B- side effect is tremor

C- they usually avoided or used with caution in patient > 70 years because of an increase risk of cognitive impairment

D- they decrease gastric motility

Q16 Score: 0.35

A- selective

B- non selective

C- all the above

Q17 Score: 0.35

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Q18 Score: 0.35

A- adding lithium

B- adding folate

C- adding omega - 3 fatty acids

D- adding an anticonvulsant

Q19 Score: 0.35

A- Allopurinol and febuxostat are decrease serum uric acid

B- is increase uric acid excretion

C- is included drug : sulfinpyrazone

D- most patient with symptomatic hyperuricemia

Q20 Score: 0.35

A- alkalinization of urine : urine PH should be maintained at 6- 6.5

B- Losartan: DM given 100 mg / dl can be uricosuric

C- Febuxostat: it is a potential alternative to allpurinol for patients with gout

D- celecoxib is COX- 2 selective inhibitor

Q21 Score: 0.35

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Q22 Score: 0.35

A- dry mouth

B- sedation

C- constipation.

D- all the above

E- non the above

Q23 Score: 0.35

A- given orally vit c

B- orally + SC

C- IV

Q24 Score: 0.35

A- probenecid

B- sulfinpyrazone

C- pegloticase

D- febuxostat

Q25 Score: 0.35

A- is recommended for patient with treatment resistant depression

B- is well tolerated , with minor visual complaints being the most frequently reported event

C- a non - invasive procedure to help fight depression

D- stimulation through a flexible

Q26 Score: 0.35

A- Naproxen+ PPI

B- can't NSAID

C- Increase NSAIDS

D- avoid NSAIDS if possible

Q27 Score: 0.35

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Q28 Score: 0.35

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Q29 Score: 0.35

A- the objective in treat OA is reduce pain

B- pharmacologic therapy is integral to achieving optimal outcomes

C- OA is primarily diagnosed on the clinical presentation

D- OA prevalence increased with age

Q30 Score: 0.35

A- emotional symptoms

B- intellectual or cognitive symptoms

C- physical symptoms

D- non the above

Q31 Score: 0.35

A- APhA

B- GAD

C- PD

D- SAD

Q32 Score: 0.35

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Q33 Score: 0.35

A- is the second line

B- all benzodiazepine are equally effective anxiolytics.

C- is the first line

D- effect on GABA

Q34 Score: 0.35

A- T- cell

B- B- cell

C- IL-6

D- IL-1

E- JAK inhibitor

Q35 Score: 0.35

A- selective

B- non selective

C- both

Q36 Score: 0.35

A- muscle tone

B- tests

C- maintaining posture

D- regulating voluntary smooth motor activity

Q37 Score: 0.35

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Q38 Score: 0.35

A- inhibitory properties at serotonin / norepinephrine reuptake transport

B- has potent antihistaminergic effect

C- antagonist at presynaptically a2- auto receptors and heteroreceptor , as well as post synaptic 5 HT2 and 5 HT3 receptor

D- the most common SE s are sedation and weight gain

Q39 Score: 0.35

A- target

B- biological

C- conventional

D- non the above

Q40 Score: 0.35

A- male gender

B- obesity

C- metabolic syndrome

D- temperature

Q41 Score: 0.35

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خطأ

Q42 Score: 0.35

A- The class of RA of NSAIDS is disease modifying therapy

B- aspirin is the prototype of traditional NSAIDS

C- corticosteroids they have bad anti- inflammatory

D- methotrexate is used symptomatic relief

Q43 Score: 0.35

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خطأ

Q44 Score: 0.35

A- NSAIDS

B- ASPIRIN

C- MONOAMINE - OXIDASE B INHIBITOR

D- WARFARIN

Q45 Score: 0.35

A- vasodilution

B- vasoconstriction

Q46 Score: 0.35

A- specific

B- non specific

C- both

Q47 Score: 0.35

A- Mirtazapine

B- Fluoxetine

C- paroxetine

D- Amitriptyline

E- vortioxetine

Q48 Score: 0.35

A- Mirtazapine

B- lithium

C- aspirin

D- A typical drug

Q49 Score: 0.35

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Q50 Score: 0.35

A- SSRIs

B- TCA

C- SNRI

D- SS

Q51 Score: 0.35

A- phenelzine

B- paroxetine

C- Amitriptyline

D- clomipramine

Q52 Score: 0.35

A- skin

B- heart

C- all the above

Q53 Score: 0.35

A- most HA are injected once weekly for either 3 or 5 weeks

B- dose of Glucosamine sulfate: 10 mg

C- works of chondroitin are blocking the enzymes that break down old cartilage

D- Glucosamine and chondroitin are the most common

Q54 Score: 0.35

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Q55 Score: 0.35

A- sertraline

B- paroxetine

C- citalopram

D- Doxepin

Q56 Score: 0.35

A- advanced age

B- gender

C- all the above

D- non the above

Q57 Score: 0.35

A- steroid

B- high protein intake

C- hyperthyroidism

D- all the above

E- non the above

Q58 Score: 0.35

A- definitive diagnosis

B- is diagnosis of joint fluid may also have an elevated WBC count with neutrophils predominating

C- the diagnosis of acute gouty arthritis may be made on the basis of presence of signs and symptoms

D- non the above

Q59 Score: 0.35

A- gender

B- bony remodeling

C- obesity

D- PIP

Q60 Score: 0.35

A- renal damage

B- renal calculi

C- clusters of urate generally surrounded by inflamed tissue

D- non the above

Q61 Score: 0.35

A- Acetaminophen should be administered initially on an as needed basis in daily doses up to 4 g

B- by single dose should exceed 1g

C- Acetaminophen should be tried initially at an adequate dose

D- Acetaminophen is effective for same indications as intermediate dose aspirin

Q62 Score: 0.35

A- is SNRIs

B- less D- D interaction than with SSRIs

C- is NDRI

D- the most common SEs are sedation and weight gain

Q63 Score: 0.35

A- anti acid decrease effect

B- protein decrease effect

C- increase beta 2 breakdowns of levadopa so decrease effect

D- all the above

Q64 Score: 0.35

A- panic disorder

B- generalized anxiety disorder

C- specific phobia

D- Posttraumatic stress disorder

Q65 Score: 0.35

A- monoarticular arthritis

B- just urate level rise in the blood without signs and symptoms

C- most patients have a second attack from 6 months to 2 years

D- complications include soft tissue damage

Q66 Score: 0.35

A- immediately

B- in addition

C- all the above

D- non the above

Q67 Score: 0.35

A- GABA

B- 5- HT2a

C- 4 - HT

D- b- blocker

Q68 Score: 0.35

A- Venlafaxine

B- Trazodone

C- Doxepin

D- Fluoxetine

E- paroxetine

Q69 Score: 0.35

A- ethanol

B- loop diuretics

C- cytotoxic drugs

D- nicotinic acid

Q70 Score: 0.35

A- high rate of diarrhea

B- prolong QT interval so consider other medication

C- helps sleep

D- longer half life compared to rest of SSRI

Q71 Score: 0.35

A- SAD can present in children of preschool to elementary school age

B- beta blocker : for not specific SAD only

C- TCA are not effective in SAD

D- beta blocker : a test dose at home

Q72 Score: 0.35

A- the crystal shape of gout: rhomboidal

B- joint involve of gout: large

C- pyrophosphate arthropathy also known as calcium pyrophosphate deposition disease

D- prevalence of gout is 0.4%, mf = 3.2 : 60- 80 year of age

Q73 Score: 0.35

A- heart

B- liver

C- joint

D- kidney

Q74 Score: 0.35

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Q75 Score: 0.35

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Q76 Score: 0.35

A- fewer side- effect

B- safety in over dose

C- high dosage titration

D- A+ B

E- B+ C

F- all the above

G- non the above

Q77 Score: 0.35

A- infection

B- lipid levels

C- all the above

D- non the above

Q78 Score: 0.35

A- most DMARDS require some form of monitoring to ensure safe therapy

B- NSAIDS and Glucocorticoid is drug of choose by DMARDS

C- DMARDS have slow onset of action

D- they have a major role in managing of RA

Q79 Score: 0.35

A- IV

B- Inhaler

C- SC

D- all the above

Q80 Score: 0.35

A- is Indirect action dopamine agonists

B- Selegiline is available in an orally disintegrating tablet designed to avoid first pass metabolism

C- Bromocriptine is not commonly used

D- side effect of rasageline are primarily GI related

Q81 Score: 0.35

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Q82 Score: 0.35

A- 12

B- 8

C- 10

D- 20

E- 25

Q83 Score: 0.35

A- SNRI and TCA

B- SSRIs and MAOIS

C- CYP and HMG reductases

D- non the above

Q84 Score: 0.35

A- delusions

B- weight gain

C- weight loss

D- hallucination

Q85 Score: 0.35

A- patients should be reminded that the optimal effect of antidepressant May not be evident for 4 to 6 weeks

B- Theoretical advantage of SSRIs : require more dosage titration than older agents

C- in practice many clinicians persist in rapidly higher doses over the first few weeks

D- all the above

Q86 Score: 0.35

A- diet

B- degradation of nucleic acid

C- purine base

D- non the above

E- all the above

Q87 Score: 0.35

A- suicide

B- ECT

C- VNS

D- TMS

Q88 Score: 0.35

A- colchine

B- corticosteroids

C- naproxen

D- ALL THE ABOVE

Q89 Score: 0.35

A- suffient fiber and protein

B- alpha - Tocopherol , Q10 - CO - enzyme

C- Vit E , C

D- all the above

Q90 Score: 0.35

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خطأ

Q91 Score: 0.35

A- phenelzine

B- Amitriptyline

C- citalopram

D- sertraline

E- Duloxetine

Q92 Score: 0.35

A- anti depression

B- herbals

C- anti convulsants

D- antibiotics

Q93 Score: 0.35

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خطأ

Q94 Score: 0.35

A- 30- 50%

B- 70- 90%

C- 10- 15%

D- 60- 80%

Q95 Score: 0.35

A- over production of uric acid

B- combined of the above two mechanism

C- under excretion of UA

D- non the above

Q96 Score: 0.35

A- patient age

B- cost

C- patient preference

D- all the above

Q97 Score: 0.35

A- for 6- 9 month

B- never add single new drug to therapy

C- give drug not intermittent

Q98 Score: 0.35

A- is metabolized by mono amine oxidase

B- an inert neutral amino acid with no known pharmacologic effect

C- including L- dopa

D- adverse effect is seizure

Q99 Score: 0.35

A- TCA

B- SNRI

C- SSRI

D- MOA

Q100 Score: 0.35

A- anxiety

B- depression

C- eye

D- otitis media

Q101 Score: 0.35

A- on regular diet

B- normal individual

C- over producers

D- under excretors of uric acid

Q102 Score: 0.35

A- tremor

B- Dyskinasea

C- bradykinesia

D- postural instability

Q103 Score: 0.35

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خطأ

Q104 Score: 0.35

A- 100 mg

B- 300 mg

C- 500 mg

D- 200 mg

Q105 Score: 0.35

A- fluxetine

B- hypothyroidsem

C- paroxetine

D- vanflaxine

Q106 Score: 0.35

A- SSRI

B- SNRI

C- TCA

D- FLX

Q107 Score: 0.35

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Q108 Score: 0.35

A- hip

B- pruritus

C- phototoxicity

D- dermatitis

Q109 Score: 0.35

A- 5HT2C

B- 5HT3

C- 5HT1A

D- 5HT2A

E- 5HT2C

F- all the above

Q110 Score: 0.35

A- methotrexate , sulfasalazine , hydroxy chloroquine is triple therapy

B- TNF- alpha is type of symptomatic relief

C- Minocycline is a tetracycline antibiotic

D- gold compound : May be given as IM or Oral

Q111 Score: 0.35

A- ibuprofen

B- rofecoxib

C- diclofenac

D- all the above

E- non the above

Q112 Score: 0.35

A- pulmonary TB

B- TB menengitise

C- extra pulmonary

Q113 Score: 0.35

A- panic disorder

B- social phobia

C- specific phobia

D- generalized anxiety disorder

Q114 Score: 0.35

A- IBS

B- IPD

C- MPTP

D- PARK1

Q115 Score: 0.35

A- zolpidem

B- Diazepam

C- temazepam

D- Fluoxetine

Q116 Score: 0.35

A- milder

B- acute

C- more chronic

D- A+ B

E- A+ C

F- all the above

Q117 Score: 0.35

A- 5HT1A IS ANTAGONIST

B- vomiting is 5HT3

C- SARA HAS DRINK ALCOHOL HAS MEAN RISK OF SUICIDE

D- ALL THE ABOVE

Q118 Score: 0.35

A- class D

B- class B

C- class C

D- class A

Q119 Score: 0.35

A- Benzbromarone

B- probenecid

C- sulfinpyrazone

D- rasburicase

Q120 Score: 0.35

A- FLX

B- SNRI

C- TCA

D- SSRI

Q121 Score: 0.35

A- fluoxetine

B- sertraline

C- citalopram

D- all the above

Q122 Score: 0.35

A- first 3 hours

B- first 12 hours

C- first 24 hours

D- first 50 hours

Q123 Score: 0.35

A- is the central hub for sights and sounds

B- is the emotional core of the brain whose primary role is to trigger the fear response

C- to be conscious of what you are seeing and hearing

D- is you memory centere

Q124 Score: 0.35

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Q125 Score: 0.35

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Q126 Score: 0.35

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Q127 Score: 0.35

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Q128 Score: 0.35

A- sulphasalazine

B- leflunomide

C- methotrexate

D- hydroxy chloroquine

Q129 Score: 0.35

A- dose of methotrexate : 5 mg

B- is have no monitoring

C- it is symptomatic relief of choice in RA

D- side effect of methotrexate is dry mouth

Q130 Score: 0.35

A- 3: 1

B- 2:3

c- 4: 1

D- 2:1

Q131 Score: 0.35

A- CNC

B- vomiting

C- hyperglycemia

D- fluid retention

Q132 Score: 0.35

A- second- line therapy

B- is inflammation with OA

C- cox2 inhibitors selectively block cox- 1 and not cox-2 activity

D- non the above

Q133 Score: 0.35

A- pegloticase is used in severe

B- rasburicase is Uricostatic agent

C- losartan : increase both uric acid excretion and urine oh

D- fenofibrate is also uricosuric and may be appropriate in select dyslipidemia patients with gout

Q134 Score: 0.35

A- radiographic changes

B- laboratory tests

C- signs

Q135 Score: 0.35

A- is functional impairment

B- is remission , patient should be free of panic attacks

C- is minimal agoraphobic avoidance

D- all the above

Q136 Score: 0.35

A- congenital or development deformities

B- erratic new bone formaion

C- bony remodeling

D- development of osteophytes

Q137 Score: 0.35

A- 29C

B- 33C

C- 21C

D- 37C

Q138 Score: 0.35

A- maintain joint function

B- response to colchicine treatment may suggest t tthe diagnosis

C- achieve rapid

D- avoid treatment related adverse effects

Q139 Score: 0.35

A- Levodopa

B- agents of interest are creatine and isradipine

B- dopamine agonist

D- all the above

Q140 Score: 0.35

A- selective

B- non selective

C- all the above

Q141 Score: 0.35

A- microfractures

B- the earliest stage of OA

C- subchondral bone

D- progressive loss of joint space

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